Social status

Social status links metabolic syndrome to breast cancer survival in AA women

Social status links metabolic syndrome to breast cancer survival in AA women Interview with:

Dr. Greco

Giampaolo Greco PhD MPH

assistant professor
Department of Population Health Science and Policy
Icahn School of Medicine at Mount Sinai What is the background of this study?

Response: The motivation for our study was to understand why the death rate from breast cancer is much higher in African American women than in white women, despite the fact that these groups have a similar incidence rate of breast cancer. .

Metabolic syndrome, a group of metabolic abnormalities that includes abdominal obesity, hypertension, hyperglycemia, and dyslipidemia, is more common in African American women and may be a risk factor for breast cancer.

Subjective social status (SSS) is individuals’ perception of their own rank in the social hierarchy and complements other parameters of socioeconomic status, such as income and education, considered more objective. Socioeconomic status is associated with cardiovascular and mental health. Although objective measures of social status are associated with poorer breast cancer outcomes, the relationship between SSS and breast cancer is uncertain. What are the main results?

Response: Our study was conducted on 1206 women with newly diagnosed breast cancer.

First, we found that subjective social status was an independent predictor of metabolic syndrome severity in women with breast cancer, controlling for age, income, education, diet and exercise.

Second, at the same level of income and education, the SSS of black women was on average lower than that of white women. The difference was particularly striking at the highest level of income and education. In other words, black women perceive their position on the American social ladder below that of white women, even within the same education and income level groups. What should readers take away from your report?

Response: SSS, independent of objective socioeconomic parameters, is associated with the metabolic syndrome, a risk factor for breast cancer. In addition, subjective social status is biased by race: lower among black women compared to white women at equivalent income and education levels. The discrepancy in perceived social status and its association with more severe metabolic syndrome in African American women may contribute to their poorer breast cancer outcomes. What recommendations do you have for future research as a result of this work?

Response: The link between SSS, metabolic syndrome and breast cancer provides new evidence on the interrelationship between our socio-economic environment and our health. Research addressing this significant disparity must focus on the problems and solutions that lie both within and beyond our health care delivery system.

I have no disclosure

Funding for this study came from NCI/NIH R01CA171558 to NB and DLR

Quote: ASCO Annual Meeting 2021

Race, subjective social status and metabolic syndrome in women with breast cancer.

Giampaolo Greco, Emily J. Gallagher, Derek Leroith, Sylvia Lin, Radhi Yagnik, Sheldon M. Feldman, Brigid K. Killelea, Neil B Friedman, Melissa Louise Pilewskie, Lydia Choi, Nina A. Bickell; Icahn School of Medicine at Mount Sinai, New York, NY; Division of Endocrinology, Icahn School of Medicine at Mount Sinai, New York, NY; Mount Sinai Medical Center, New York, NY; Columbia University Col…

J Clin Oncol 39, 2021 (suppl 15; abstract 560)

DOI: 10.1200/JCO.2021.39.15_suppl.560


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